Button click event not firing after Text box Textchanged event

Hi
I have a web page which has some text boxes and button to save it.
Initially button will be disabled. When I change the text in the text box, I enable the button. But the problem is, I cannot directly fire button click event after changing a text.
For ex:- I have 5 text boxes. When I change the value in the first text box, button enables but if I change any text box and clicking on the save button directly, will not fire button click event and instead text box change event fires.
I can see this works fine if I tab out and then click on the button but I want it to fire without tabbing out.
Thanks in advance.
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