Best way to approach developing table selection grid [asp.net VB]

I need to develop a table which is going to allow a user to select multiple columns. When they do their selection, they can save which uploads the values to the database.

I have implemented something like this before and i have used many hidden textboxes, one textbox for each cell, however i was wondering if there was an easier way to deal with the data on the back end without having to create so many textboxes which i then loop through.
So for example is there a way i can create a checkbox list, place one checkbox in each cell and then just simply loop through the list of each row.
If there are any other easier methods to achieve this, please let me know.
Thank you!