Need Opinion on App Key settings from database

My co worker and I are going to pull our 'web.config app key' settings from the database instead of the web.config file. We are doing this because the development, staging, and production settings are changing more than we would like to redeploy out.  After saying that and knowing we have a Ntier web application, what is the best way to pass all of those settings to the Service/Business layer and Data Layers?  I know we can do it via the parameters as we need or maybe doing it somehow in the Base Repository in our Data layer?
We are using C# code/ Asp.net 4.0