File Upload to user defined location

Hello,
I have a file upload page in which I am settting the server mappath of where to put the file.
I need to change this to a user defined sub- directory; put a variable in place of C:\UploadedUserFiles\ selected from a browse button. Is this possible?
    uploads(i).SaveAs("C:\UploadedUserFiles\" + c)                     Span1.InnerHtml = "File Uploaded Sucessfully.