Need design guidence for .Net web application

Hi There, I want to design .net web application with following requirement. 1. Should work on Desktop, tablets, iPad and mobile phone. Means that should contain responsive design. 2. Should work on all major browsers (IE 8 and above, Firefox, Safari and Chrome). 3. Also need to develop mobile application which contains with limited functionality. Means some specific modules like Customer Bills, Summary details and work flow for approvals. If want to publish that application on Windows and Android phones then need two separate application development or single application can work on that? Can you please advise what will be better design for that in .Net technology and techniques that I can use in that like  jQuery, Mobile jQuery, Bootstrap etc..? Regards, Ankush