SQL Server Mgmt Studio can't connect to MICROSOFT##SSEE.

Running SQL Server 2008 R2 and express (Microsoft ##SSEE) on Windows Server 2008 R2
C:\Program Files\Microsoft SQL Server\MSSQL10_50.MSSQLSERVER\MSSQL\Binn\sqlservr.exe" -sMSSQLSERVER
C:\Windows\SYSMSI\SSEE\MSSQL.2005\MSSQL\Binn\sqlservr.exe -sMICROSOFT##SSEE
Both instances are running.
I can connect to SQL 2008 R2 as the domain admin and local admin.
I cannot connect to Express version with either domain or local admin.  Running SQL Server Management Studio 'as administrator' I get the same error message when trying to connect to the express database. I browse to the instance and select it, so don't understand why its complaining about not being found. Not accessible is another question, however its on the same server that I am running the studio tool and I am running as local admin, domain admin also causes this error.

I do have sharepoint running that is using that SSEE database instance, would that block the ...