Can I use the Win32 API from a .NET Framework program?

Answer:

Yes. Using platform invoke, .NET Framework programs can access native code libraries by means of static DLL entry points.
Here is an example of C# calling the Win32 MessageBox function:
using System;
using System.Runtime.InteropServices;

class MainApp
{
[DllImport("user32.dll", EntryPoint="MessageBox")]
public static extern int MessageBox(int hWnd, String strMessage, String strCaption, uint uiType);

public static void Main()
{
MessageBox( 0, "Hello, this is PInvoke in operation!", ".NET", 0 );
}
}